Gonzalez Alam, Tirso Rene del Jesus orcid.org/0000-0003-4510-2441, Karapanagiotidis, Theodoros orcid.org/0000-0002-0813-1019, Smallwood, Jonathan orcid.org/0000-0002-7298-2459 et al. (1 more author) (2019) Degrees of lateralisation in semantic cognition:Evidence from intrinsic connectivity. Neuroimage. 116089. ISSN 1053-8119
Abstract
The semantic network is thought to include multiple components, including heteromodal conceptual representations and semantic control processes that shape retrieval to suit the circumstances. Much of this network is strongly left-lateralised; however, work to date has not considered whether separable components of semantic cognition have different degrees of lateralisation. This study examined intrinsic connectivity of four regions implicated in heteromodal semantic cognition, identified using large scale meta-analyses: two sites which have been argued to act as heteromodal semantic hubs in anterior temporal lobe (ATL) and angular gyrus (AG); and two sites implicated in semantic control in inferior frontal (IFG) and posterior middle temporal gyri (pMTG). We compared the intrinsic connectivity of these sites in left hemisphere (LH) and right hemisphere (RH), and linked individual differences in the strength of within- and between-hemisphere connectivity from left-lateralised seeds to performance on semantic tasks, in a sample of 196 healthy volunteers. ATL showed more symmetrical patterns of intrinsic connectivity than the other three sites. The connectivity between IFG and pMTG was stronger in the LH than the RH, suggesting that the semantic control network is strongly left-lateralised. The degree of hemispheric lateralisation also predicted behaviour: participants with stronger intrinsic connectivity within the LH had better semantic performance, while those with stronger intrinsic connectivity between left pMTG and homotopes of semantic regions in the RH performed more poorly on judgements of weak associations, which require greater control. Stronger connectivity between left AG and visual cortex was also linked to poorer perceptual performance. Overall, our results show that hemispheric lateralisation is particularly important for the semantic control network, and that this lateralisation has contrasting functional consequences for the retrieval of dominant and subordinate aspects of knowledge.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 Published by Elsevier Inc. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. |
Keywords: | fMRI,Hemispheric differences,Intrinsic connectivity,Lateralisation,Resting state,Semantic cognition,Semantic control |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Psychology (York) > York Neuroimaging Centre The University of York > Faculty of Sciences (York) > Psychology (York) |
Depositing User: | Pure (York) |
Date Deposited: | 11 Oct 2019 08:20 |
Last Modified: | 08 Feb 2025 00:35 |
Published Version: | https://doi.org/10.1016/j.neuroimage.2019.116089 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1016/j.neuroimage.2019.116089 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:152023 |
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