Zhang, Z, Thorne, JL orcid.org/0000-0002-3037-8528 and Moore, JB (2019) Vitamin D and nonalcoholic fatty liver disease. Current Opinion in Clinical Nutrition and Metabolic Care, 22 (6). pp. 449-458. ISSN 1363-1950
Abstract
Purpose of review: Vitamin D deficiency may impact disease progression of nonalcoholic fatty liver disease (NAFLD). The aim of this work was to review recent studies examining either vitamin D status or the effects of supplementation in patients with NAFLD, along with investigating the roles of genetic polymorphisms and the gut microbiome.
Recent findings: Six heterogeneous observational studies of vitamin D status, and four randomized controlled intervention trials of vitamin D supplementation in NAFLD were conflicting. All studies were hampered by the challenges of diagnosing NAFLD, were underpowered, and lacked data on clinically important outcomes. The results of three cross-sectional studies, including a Mendelian randomization study, provide limited evidence for a role for genetic modifiers of vitamin D status in NAFLD. Genetic and experimental evidence suggests that vitamin D and the vitamin D receptor (VDR) may influence the gut microbiome in health and disease.
Summary: The evidence relating either lower vitamin D status to the prevalence and severity of NAFLD, or examining vitamin D supplementation in patients with NAFLD is inconclusive. Larger, higher quality trials with relevant endpoints are needed. Further mechanistic studies on the roles of vitamin D and VDR in influencing the gut–liver axis in NAFLD are warranted.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 Wolters Kluwer Health, Inc. All rights reserved. This is an author produced version of an article published in Current Opinion in Clinical Nutrition & Metabolic Care. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | microbiome; nonalcoholic fatty liver disease; polymorphisms; supplementation; vitamin D status |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) > FSN Chemistry and Biochemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 08 Oct 2019 10:19 |
Last Modified: | 01 Nov 2020 01:38 |
Status: | Published |
Publisher: | Lippincott Williams & Wilkins |
Identification Number: | 10.1097/MCO.0000000000000605 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:151893 |