Clark, E, Peel, AD orcid.org/0000-0002-9914-3508 and Akam, M (2019) Arthropod segmentation. Development, 146 (18). dev170480. ISSN 0950-1991
Abstract
There is now compelling evidence that many arthropods pattern their segments using a clock-and-wavefront mechanism, analogous to that operating during vertebrate somitogenesis. In this Review, we discuss how the arthropod segmentation clock generates a repeating sequence of pair-rule gene expression, and how this is converted into a segment-polarity pattern by ‘timing factor’ wavefronts associated with axial extension. We argue that the gene regulatory network that patterns segments may be relatively conserved, although the timing of segmentation varies widely, and double-segment periodicity appears to have evolved at least twice. Finally, we describe how the repeated evolution of a simultaneous (Drosophila-like) mode of segmentation within holometabolan insects can be explained by heterochronic shifts in timing factor expression plus extensive pre-patterning of the pair-rule genes.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019. Published by The Company of Biologists Ltd. This is an open access article under the terms of the Creative Commons https://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) |
Keywords: | Arthropods; Segmentation; Patterning; Pair-rule genes; Drosophila; Tribolium |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 01 Oct 2019 14:36 |
Last Modified: | 28 Oct 2019 09:28 |
Status: | Published |
Identification Number: | 10.1242/dev.170480 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:151486 |