Abou Elmaaty, TM, Russell, SJ orcid.org/0000-0003-0339-9611, Goswami, P et al. (2 more authors) (2019) A new approach for the functionalisation of polysulfone with β-cyclodextrin. Materials Research Express, 6 (10). 105310. ISSN 2053-1591
Abstract
Functionalisation of polysulfone (PSU) with β-cyclodextrin (β.CD) is a potential vehicle for the design of drug delivery devices via complexation. In this approach, PSU film was first pre-activated by air plasma to facilitate a post-grafting reaction with methacrylic acid (MAA) and then amination by diamino-dipropylamine (DADPA). Finally, β.CD was anchored on to PSU-PMAA-DADPA surfaces via covalent bonding with amino groups. Creation of functional groups was confirmed by ATR-FTIR and functionalisation of PSU-PMAA-DADPA film with β.CD was verified by UV absorbance following immersion in phenolphthalein (PHP), which formed inclusion complexes with the attached β.CD. A reduction in absorbance of the PHP solution was observed, together with an increase in PHP exhaustion on to the PSU-PMAA-DADPA films as a result of functionalisation with β.CD. Increasing the amount of β.CD attached to the PSU-PMAA-DADPA films progressively increased PHP exhaustion until saturation was achieved.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019, IOP Publishing Ltd. This is an author-created, un-copyedited version of an article published in Materials Research Express. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.1088/2053-1591/ab35f3. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Arts, Humanities and Cultures (Leeds) > School of Design (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 18 Sep 2019 10:00 |
Last Modified: | 26 Jul 2020 00:39 |
Status: | Published |
Publisher: | IoP Publishing |
Identification Number: | 10.1088/2053-1591/ab35f3 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:150986 |