Sallach, J. Brett orcid.org/0000-0003-4588-3364, Crawford, Robert, Li, Hui et al. (4 more authors) (2019) Activated carbons of varying pore structure eliminate the bioavailability of 2,3,7,8-tetrachlorodibenzo-p-dioxin to a mammalian (mouse) model. Science of the Total Environment. pp. 2231-2238. ISSN 0048-9697
Abstract
The use of activated carbon (AC) as an in situ sorbent amendment to sequester polychlorinated-dibenzo-p-dioxins and furans (PCDD/Fs) present in contaminated soils and sediments has recently gained attention as a novel remedial approach. This remedy could be implemented at much lower cost while minimizing habitat destruction as compared to traditional remediation technologies that rely on dredging/excavation and landfilling. Several prior studies have demonstrated the ability of AC amendments to reduce pore water concentrations and hence bioaccumulation of PCDD/Fs in invertebrate species. However, our recent study was the first to show that AC had the ability to sequester 2,3,7,8‑tetrachlorodibenzo‑p‑dioxin (TCDD) in a form that eliminated bioavailability to a mammalian (mouse) model. Here we show that three commercially available ACs, representing a wide range of pore size distributions, were equally effective in eliminating the bioavailability of TCDD based upon two sensitive bioassays, hepatic induction of cyp1A1 mRNA and immunoglobulin M antibody-forming cell response. These results provide direct evidence that a wide range of structurally diverse commercially available ACs may be suitable for use as in situ sorbent amendments to provide a cost-effective remedy for PCDD/F contaminated soils and sediments. Potentially, adaption of this technology would minimize habitat destruction and be protective of ecosystem and human health.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Keywords: | Immune response,Remediation,Sorbent amendments,TCDD |
Dates: |
|
Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Environment and Geography (York) The University of York > Faculty of Sciences (York) > Stockholm Environment Institute at York (York) |
Depositing User: | Pure (York) |
Date Deposited: | 17 Sep 2019 08:40 |
Last Modified: | 07 Feb 2025 00:26 |
Published Version: | https://doi.org/10.1016/j.scitotenv.2018.09.270 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1016/j.scitotenv.2018.09.270 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:150942 |