Cooper, RJ orcid.org/0000-0001-5255-1486, Wilcox, RK orcid.org/0000-0003-2736-7104 and Jones, AC orcid.org/0000-0002-4984-7507 (2019) Finite element models of the tibiofemoral joint: A review of validation approaches and modelling challenges. Medical Engineering & Physics, 74. pp. 1-12. ISSN 1350-4533
Abstract
The knee joint is a complex mechanical system, and computational modelling can provide vital information for the prediction of disease progression and of the potential for therapeutic interventions. This review provides an overview of the challenges involved in developing finite element models of the tibiofemoral joint, including the representation of appropriate geometry and material properties, loads and motions, and establishing pertinent outputs. The importance of validation for computational models in biomechanics has been highlighted by a number of papers, and finite element models of the tibiofemoral joint are a particular area in which validation can be challenging, due to the complex nature of the knee joint, its geometry and its constituent tissue properties. A variety of study designs have emerged to tackle these challenges, and these can be categorised into several different types. The role of validation, and the strategies adopted by these different study types, are discussed. Models representing trends and sensitivities often utilise generic representations of the knee and provide conclusions with relevance to general populations, usually without explicit validation. Models representing in vitro specimens or in vivo subjects can, to varying extents, be more explicitly validated, and their conclusions are more subject-specific. The potential for these approaches to examine the effects of patient variation is explored, which could lead to future applications in defining how treatments may be stratified for subgroups of patients.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 The Authors. Published by Elsevier Ltd on behalf of IPEM.. This is an open access article under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
Keywords: | Finite element; Computational model; Knee; Tibiofemoral; Osteoarthritis; Meniscus; Cartilage; Validation; Ligaments; Review |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Mechanical Engineering (Leeds) > Institute of Medical and Biological Engineering (iMBE) (Leeds) |
Funding Information: | Funder Grant number EPSRC EP/P001076/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 29 Aug 2019 09:01 |
Last Modified: | 09 Dec 2019 13:48 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.medengphy.2019.08.002 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:150115 |