Arafat, MT, Tronci, G orcid.org/0000-0002-9426-4220, Wood, DJ orcid.org/0000-0001-8269-9123 et al. (1 more author) (2019) In-situ crosslinked wet spun collagen triple helices with nanoscale-regulated ciprofloxacin release capability. Materials Letters, 255. 126550. ISSN 0167-577X
Abstract
The design of antibacterial-releasing coatings or wrapping materials with controlled drug release capability is a promising strategy to minimise risks of infection and medical device failure in vivo. Collagen fibres have been employed as medical device building block, although they still fail to display controlled release capability, competitive wet-state mechanical properties, and retained triple helix organisation. We investigated this challenge by pursuing a multiscale design approach integrating drug encapsulation, in-situ covalent crosslinking and fibre spinning. By selecting ciprofloxacin (Cip) as a typical antibacterial drug, wet spinning was selected as a triple helix-friendly route towards Cip-encapsulated collagen fibres; whilst in–situ crosslinking of fibre-forming triple helices with 1,3–phenylenediacetic acid (Ph) was hypothesised to yield Ph-Cip π-π stacking aromatic interactions and enable controlled drug release. Higher tensile modulus and strength were measured in Ph–crosslinked fibres compared to state-of-the-art carbodiimide–crosslinked controls. Cip-encapsulated Ph-crosslinked fibres revealed decreased elongation at break and significantly-enhanced drug retention in vitro with respect to Cip-free variants and carbodiimide-crosslinked controls, respectively. This multiscale manufacturing strategy provides new insight aiming at wet spun collagen triple helices with nanoscale-regulated tensile properties and drug release capability.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 Elsevier B.V. All rights reserved. This is an author produced version of an article published in Materials Letters. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Arts, Humanities and Cultures (Leeds) > School of Design (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > Oral Biology (Leeds) |
Funding Information: | Funder Grant number EPSRC Not Known EPSRC Not Known The Clothworkers Foundation ANDREW BLESSLEY EPSRC EP/K029592/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 12 Sep 2019 15:15 |
Last Modified: | 16 Aug 2020 00:38 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.matlet.2019.126550 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:149906 |