Yu, H, Guo, Z, Wang, S et al. (8 more authors) (2019) Fabrication of Hybrid Materials from Titanium Dioxide and Natural Phenols for Efficient Radical Scavenging against Oxidative Stress. ACS Biomaterials Science and Engineering, 5 (6). pp. 2778-2785. ISSN 2373-9878
Abstract
Oxidative stress caused by free radicals is one of the great threats to inflict intracellular damage. Here, we report a convenient approach to the synthesis, characterization, and evaluation of the radical activity of titanium-based composites. We have investigated the potential of natural antioxidants (curcumin, quercetin, catechin, and vitamin E) as radical scavengers and stabilizers. The titanium oxide composites were prepared via three steps including sol–gel synthesis, carboxylation, and esterification. The characterization of the titanium–phenol composites was carried out by FTIR, PXRD, UV–vis and SEM methods. The radical scavenging ability of the novel materials was evaluated using DPPH and an in vitro LPO assay using isolated rat liver mitochondria. The novel materials exhibit both a higher stability and an antioxidant activity in comparison to bare TiO2. It was found that curcumin and quercetin based composites show the highest antioxidant efficiency among the composites under study followed by catechin and vitamin E based materials. The results from an MTT assay carried out on the Caco-2 cell line indicate that the composites do not contribute to the cytotoxicity in vitro. This study demonstrates that a combination of powerful antioxidants with titanium dioxide can change its functional properties and provide a convenient strategy against oxidative stress.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 American Chemical Society. This is an author produced version of a paper published in ACS Biomaterials Science and Engineering. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | oxidative stress; titanium dioxide; polyphenols; surface modification; antioxidants; LPO and MTT assay; cytotoxicity |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Colour Science (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Inorganic Chemistry (Leeds) The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) > FSN Nutrition and Public Health (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 11 Jul 2019 09:12 |
Last Modified: | 03 May 2020 00:38 |
Status: | Published |
Publisher: | American Chemical Society |
Identification Number: | 10.1021/acsbiomaterials.9b00535 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:148416 |