Lichman, Benjamin R. orcid.org/0000-0002-0033-1120, O'Connor, Sarah E. and Kries, Hajo (2019) Biocatalytic Strategies towards [4+2] Cycloadditions. Chemistry - A European Journal. pp. 6864-6877. ISSN 1521-3765
Abstract
Long sought after [4+2] cyclases have sprouted up in numerous biosynthetic pathways in recent years, raising hopes for biocatalytic solutions to cycloaddition catalysis, an important problem in chemical synthesis. In a few cases, detailed pictures of the inner workings of these catalysts have emerged, but intense efforts to gain deeper understanding are underway by means of crystallography and computational modelling. This Minireview aims to shed light on the catalytic strategies that this highly diverse family of enzymes employs to accelerate and direct the course of [4+2] cycloadditions with reference to small-molecule catalysts and designer enzymes. These catalytic strategies include oxidative or reductive triggers and lid-like movements of enzyme domains. A precise understanding of natural cycloaddition catalysts will be instrumental for customizing them for various synthetic applications.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details. |
Keywords: | biocatalysis,Diels–Alderase,enzyme design,enzyme mechanism,[4+2] cyclase |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Biology (York) |
Depositing User: | Pure (York) |
Date Deposited: | 08 Apr 2019 10:20 |
Last Modified: | 19 Mar 2025 00:08 |
Published Version: | https://doi.org/10.1002/chem.201805412 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1002/chem.201805412 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:144635 |
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