Jarosz-Griffiths, HH orcid.org/0000-0001-5154-4815, Holbrook, J, Lara-Reyna, S et al. (1 more author) (2019) TNF receptor signalling in autoinflammatory diseases. International Immunology, 31 (10). pp. 369-348. ISSN 0953-8178
Abstract
Autoinflammatory syndromes are a group of disorders characterised by recurring episodes of inflammation as a result of specific defects in the innate immune system. Patients with autoinflammatory disease present with recurrent outbreaks of chronic systemic inflammation that are mediated by innate immune cells, for the most part. A number of these diseases arise from defects in the tumour necrosis factor (TNF) receptor signalling pathway leading to elevated levels of inflammatory cytokines. Elucidation of the molecular mechanisms of these recently defined autoinflammatory diseases has led to a greater understanding of the mechanisms of action of key molecules involved in TNFR signalling, particularly those involved in ubiquitination, as found in haploinsufficiency of A20 (HA20), otulipenia/otulin-related autoinflammatory syndrome (ORAS) and linear ubiquitin chain assembly complex (LUBAC) deficiency. In this review we also address other TNFR signalling disorders such as (TNF) receptor-associated periodic syndrome (TRAPS), RELA haploinsufficiency, RIPK1-associated immunodeficiency and autoinflammation, X-linked ectodermal dysplasia and immunodeficiency (X-EDA-ID) and we review the most recent advances surrounding these diseases and therapeutic approaches currently used to target these diseases. Finally, we explore therapeutic advances in TNF-related immune based therapies and explore new approaches to target disease-specific modulation of autoinflammatory diseases.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2019, The Japanese Society for Immunology. All rights reserved. This is an author produced version of a paper published in International Immunology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | TNF therapeutics, ubiquitination |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Translational Medicine (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) > Clinical Musculoskeletal Medicine (LIRMM) (Leeds) |
Funding Information: | Funder Grant number Cystic Fibrosis Trust SRC009 |
Depositing User: | Symplectic Publications |
Date Deposited: | 10 Apr 2019 09:10 |
Last Modified: | 06 Mar 2020 01:38 |
Status: | Published |
Publisher: | Oxford University Press |
Identification Number: | 10.1093/intimm/dxz024 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:144552 |