Wodak, Shoshana J, Paci, Emanuele, Dokholyan, Nikolay V et al. (36 more authors) (2019) Allostery in Its Many Disguises:From Theory to Applications. Structure. ISSN 1878-4186
Abstract
Allosteric regulation plays an important role in many biological processes, such as signal transduction, transcriptional regulation, and metabolism. Allostery is rooted in the fundamental physical properties of macromolecular systems, but its underlying mechanisms are still poorly understood. A collection of contributions to a recent interdisciplinary CECAM (Center Européen de Calcul Atomique et Moléculaire) workshop is used here to provide an overview of the progress and remaining limitations in the understanding of the mechanistic foundations of allostery gained from computational and experimental analyses of real protein systems and model systems. The main conceptual frameworks instrumental in driving the field are discussed. We illustrate the role of these frameworks in illuminating molecular mechanisms and explaining cellular processes, and describe some of their promising practical applications in engineering molecular sensors and informing drug design efforts.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | Copyright © 2019. Published by Elsevier Ltd. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. |
Dates: |
|
Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Physics (York) |
Funding Information: | Funder Grant number EPSRC EP/N031431/2 |
Depositing User: | Pure (York) |
Date Deposited: | 07 Mar 2019 14:40 |
Last Modified: | 22 Jan 2025 00:11 |
Published Version: | https://doi.org/10.1016/j.str.2019.01.003 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1016/j.str.2019.01.003 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:143430 |
Downloads
Filename: Master_Suppl_Allostery_Structure_DEC07_ref_2018.pdf
Description: Master-Suppl-Allostery-Structure-DEC07-ref-2018
Licence: CC-BY-NC-ND 2.5
Filename: Figures_Main_Review_Allostery_Structure_DEC08_2018.pdf
Description: Figures-Main-Review-Allostery-Structure-DEC08-2018
Licence: CC-BY-NC-ND 2.5
Filename: Master_Main_Allostery_Structure_DEC08_Formatted_2018.pdf
Description: Master-Main-Allostery-Structure-DEC08-Formatted-2018
Licence: CC-BY-NC-ND 2.5