Rickman, J, Tronci, G orcid.org/0000-0002-9426-4220, Liang, H et al. (1 more author) (2019) Rotation-assisted wet-spinning of UV-cured gelatin fibres and nonwovens. Journal of Materials Science, 54 (14). pp. 10529-10547. ISSN 0022-2461
Abstract
Photoinduced network formation is an attractive strategy for designing water-insoluble gelatin fibres as medical device building blocks and for enabling late-stage property customisation. However, mechanically competent, long-lasting filaments are still hard to realise with current photoactive, e.g. methacrylated, gelatin systems due to inherent spinning instability and restricted coagulation capability. To explore this challenge, we present a multiscale approach combining the synthesis of 4-vinylbenzyl chloride (4VBC)-functionalised gelatin (Gel-4VBC) with a voltage-free spinning and UV-curing process so that biopolymer networks in the form of either individual fibres or nonwovens could be successfully manufactured. In comparison with state-of-the-art methacrylated gelatin, the mechanical properties of UV-cured Gel-4VBC fibres were readily modulated by adjustment of coagulation conditions, so that an ultimate tensile strength and strain at break of 25 ± 4–74 ± 3 MPa and 1.7 ± 0.3–8.6 ± 0.5% were measured, respectively. The sequential functionalisation/spinning route proved to be highly scalable, so that one-step spun-laid formation of fibroblast-friendly nonwoven fabrics was successfully demonstrated with wet-spun Gel-4VBC fibres. The presented approach could be exploited to generate a library of gelatin building blocks tuneable from the molecular to the macroscopic level to deliver computer-controlled extrusion of fibres and nonwovens according to defined clinical applications.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Arts, Humanities and Cultures (Leeds) > School of Design (Leeds) |
Funding Information: | Funder Grant number The Clothworkers Foundation ANDREW BLESSLEY |
Depositing User: | Symplectic Publications |
Date Deposited: | 06 Mar 2019 13:27 |
Last Modified: | 25 Jun 2023 21:44 |
Status: | Published |
Publisher: | Springer Verlag |
Identification Number: | 10.1007/s10853-019-03498-5 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:143325 |
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