Levenstein, MA orcid.org/0000-0002-2309-3743, Anduix-Canto, C, Kim, YY orcid.org/0000-0002-8503-4554 et al. (13 more authors) (2019) Droplet Microfluidics XRD Identifies Effective Nucleating Agents for Calcium Carbonate. Advanced Functional Materials, 29 (19). 1808172. ISSN 1616-301X
Abstract
The ability to control crystallization reactions is required in a vast range of processes including the production of functional inorganic materials and pharmaceuticals and the prevention of scale. However, it is currently limited by a lack of understanding of the mechanisms underlying crystal nucleation and growth. To address this challenge, it is necessary to carry out crystallization reactions in well‐defined environments, and ideally to perform in situ measurements. Here, a versatile microfluidic synchrotron‐based technique is presented to meet these demands. Droplet microfluidic‐coupled X‐ray diffraction (DMC‐XRD) enables the collection of time‐resolved, serial diffraction patterns from a stream of flowing droplets containing growing crystals. The droplets offer reproducible reaction environments, and radiation damage is effectively eliminated by the short residence time of each droplet in the beam. DMC‐XRD is then used to identify effective particulate nucleating agents for calcium carbonate and to study their influence on the crystallization pathway. Bioactive glasses and a model material for mineral dust are shown to significantly lower the induction time, highlighting the importance of both surface chemistry and topography on the nucleating efficiency of a surface. This technology is also extremely versatile, and could be used to study dynamic reactions with a wide range of synchrotron‐based techniques.
Metadata
Item Type: | Article |
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Copyright, Publisher and Additional Information: | © 2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: Levenstein, M. A., Anduix‐Canto, C., Kim, Y.‐Y., Holden, M. A., González Niño, C., Green, D. C., Foster, S. E., Kulak, A. N., Govada, L., Chayen, N. E., Day, S. J., Tang, C. C., Weinhausen, B., Burghammer, M., Kapur, N., Meldrum, F. C., Adv. Funct. Mater. 2019, 29, 1808172, which has been published in final form at https://doi.org/10.1002/adfm.201808172. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | bioactive glass; crystallization; droplet microfluidics; nucleation; powder X‐ray diffraction; serial crystallography; synchrotron radiation |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Mechanical Engineering (Leeds) > Institute of Engineering Thermofluids, Surfaces & Interfaces (iETSI) (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Inorganic Chemistry (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Physics and Astronomy (Leeds) > Molecular & Nanoscale Physics |
Funding Information: | Funder Grant number EPSRC EP/M003027/1 EPSRC EP/N002423/1 EU - European Union 788968 |
Depositing User: | Symplectic Publications |
Date Deposited: | 05 Mar 2019 11:59 |
Last Modified: | 13 Mar 2020 01:38 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/adfm.201808172 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:143213 |