Holbrook, J, Lara-Reyna, S, Jarosz-Griffiths, H orcid.org/0000-0001-5154-4815 et al. (1 more author) (2019) Tumour necrosis factor signalling in health and disease. F1000 Research, 8 (F1000 Faculty Rev). 111. ISSN 2046-1402
Abstract
The master pro-inflammatory cytokine, tumour necrosis factor (TNF), has been shown to modulate multiple signalling pathways, with wide-ranging downstream effects. TNF plays a vital role in the typical immune response through the regulation of a number of pathways encompassing an immediate inflammatory reaction with significant innate immune involvement as well as cellular activation with subsequent proliferation and programmed cell death or necrosis. As might be expected with such a broad spectrum of cellular effects and complex signalling pathways, TNF has also been implicated in a number of disease states, such as rheumatoid arthritis, ankylosing spondylitis, and Crohn’s disease. Since the time of its discovery over 40 years ago, TNF ligand and its receptors, TNF receptor (TNFR) 1 and 2, have been categorised into two complementary superfamilies, namely TNF (TNFSF) and TNFR (TNFRSF), and 19 ligands and 29 receptors have been identified to date. There have been significant advances in our understanding of TNF signalling pathways in the last decade, and this short review aims to elucidate some of the most recent advances involving TNF signalling in health and disease.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2019, Holbrook J et al. This is an open access article distributed under the terms of the Creative Commons Attribution Licence [https://creativecommons.org/licenses/by/4.0/], which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | TNF, TNFR, Cell death, Immunometabolism, Autoinflammatory |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) > Clinical Musculoskeletal Medicine (LIRMM) (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 26 Feb 2019 15:21 |
Last Modified: | 25 Jun 2023 21:43 |
Status: | Published |
Publisher: | F1000 Research |
Identification Number: | 10.12688/f1000research.17023.1 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:142881 |
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