Ran, Yanrui, Byrne, Fergal, Ingram, Ian D.V. et al. (1 more author) (2019) Resin swelling in mixed solvents analysed using Hansen solubility parameter space. Chemistry : A European Journal. ISSN 1521-3765
Abstract
The swelling of resins (Merrifield and HypoGel 200) in mixtures of two solvents was generally found not to vary linearly with the relative amount of each solvent in the mixture. Hansen solubility parameter (HSP) space could be used to define high, medium and low swelling regions for each resin. The variation of resin swelling with binary solvent composition could then be explained based on the HSP parameters of the two solvents and the way in which the line connecting the points corresponding to the two pure solvents bisected the swelling region for the resin. The applicability of the methodology was demonstrated by showing that an appropriate mixture of two green solvents was more effective for solid-phase peptide synthesis on Merrifield resin than use of either individual solvent and could completely replace the use of traditional polar aprotic and chlorinated solvents for this application. It was also shown that the high resin swelling area of Merrifield resin can be used to predict mixtures of green solvents that will dissolve linear, unfunctionalised polystyrene.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details. |
Keywords: | Hansen solubility parameters,binary mixture,green chemistry,resin-swelling,solid-phase peptide synthesis,solvents |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 14 Feb 2019 16:30 |
Last Modified: | 26 Nov 2024 00:41 |
Published Version: | https://doi.org/10.1002/chem.201900228 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1002/chem.201900228 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:142562 |