Borah, PK, Rappolt, M, Duary, RK et al. (1 more author) (2019) Structurally induced modulation of in vitro digestibility of amylopectin corn starch upon esterification with folic acid. International Journal of Biological Macromolecules, 129. pp. 361-369. ISSN 0141-8130
Abstract
The present study aims to identify how structural modifications of amylopectin corn starch on esterification with folic acid (FA) affects its in vitro digestion. Small angle X-ray scattering (SAXS) confirmed that at low FA esterification (5–10%), the mesophase order showed the absence of any super-structural order. However, a discotic stacking of SF forming columnar hexagonal phases and columnar helical phases (with strong optical anisotropy) was observed upon increasing FA esterification (20–40%). X-ray diffraction (XRD) evidenced the development of a V and B-type molecular packing order in SF with increased FA esterification from 20 to 40%, with a consequential increase in the percentage of slow digestible starch (SDS) and resistant starch (RS). The slower digestion phenomenon displayed a dual-phase behavior, with digestion rates k1 > k2, where k2 being ca. 0.3 of k1. Stacking over packing order appeared to be more influential in limiting the enzymatic action. A k-means clustering analysis of the total digested starch and Fourier transform infrared (FTIR) spectroscopy peak ratios (1000/1022) cm−1 indicated that 0.04 level FA substitution was crucial for slower hydrolysis of SF. This study provides structural insights for developing starch-folic acid ester derivatives that could form building-block copolymers for future development of oral drug/nutraceutical delivery vehicles with tailored starch digestion properties.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 Published by Elsevier B.V. This is an author produced version of a paper published in International Journal of Biological Macromolecules. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Starch; Folic acid; Esterification; Sructure; Digestion; SAXS |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) > FSN Colloids and Food Processing (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 12 Feb 2019 16:26 |
Last Modified: | 10 Feb 2020 01:41 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.ijbiomac.2019.02.051 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:142424 |