Knights, OB orcid.org/0000-0003-1729-1492, Cowell, DMJ, Carpenter, TM et al. (2 more authors) (2018) Plasmonic Gold Nanoparticles for Combined Photoacoustic Imaging and Plasmonic Photothermal Therapy Using a Pulsed Laser. In: 2018 IEEE International Ultrasonics Symposium (IUS). IUS 2018, 22-25 Oct 2018, Kobe, Japan. IEEE ISBN 9781538634257
Abstract
Plasmonic gold nanoparticles show potential for use in a range of cancer diagnostics and therapeutics, such as photoacoustic imaging (PAI) and plasmonic photothermal therapy (PPTT). Generally in PPTT, continuous wave (CW) lasers are used to destroy cancerous tissue. However, in order to add a diagnostic component through PAI, a pulsed wave (PW) laser is needed. If PPTT can be achieved using PW lasers then combined theranostic applications with the same laser system is possible. Additionally, AuNRs can be many different sizes but exhibit equivalent surface plasmon resonances, so the size may be significant in the efficacy of these modalities. We have demonstrated the potential for gold nanorods to be used for both PAI and PPTT. The Au10s displayed the highest photoacoustic signal amplitude and PPTT efficacy. A PW laser was shown to induce significant cell death to a lung cancer cell line with a fluence below the maximum permissible exposure, indicating the possibility for cancer theranostics with a PW laser.
Metadata
Item Type: | Proceedings Paper |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2018, IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. |
Keywords: | Radiation effects, Lung, Laser applications, Cancer, Measurement by laser beam, Laser tuning;; gold nanoparticles, photoacoustic imaging, photothermal therapy, pulsed laser, contrast agents |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Electronic & Electrical Engineering (Leeds) > Robotics, Autonomous Systems & Sensing (Leeds) |
Funding Information: | Funder Grant number Leverhulme Trust ECF-2013-247 EPSRC EP/S001069/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 05 Feb 2019 17:15 |
Last Modified: | 06 Feb 2019 17:48 |
Status: | Published |
Publisher: | IEEE |
Identification Number: | 10.1109/ULTSYM.2018.8579902 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:142056 |