Reduced habit-driven errors in Parkinson’s Disease

Abstract

Parkinson’s Disease can be understood as a disorder of motor habits. A prediction of this theory is that early stage Parkinson’s patients will display fewer errors caused by interference from previously over-learned behaviours. We test this prediction in the domain of skilled typing, where actions are easy to record and errors easy to identify. We describe a method for categorizing errors as simple motor errors or habit-driven errors. We test Spanish and English participants with and without Parkinson’s, and show that indeed patients make fewer habit errors than healthy controls, and, further, that classification of error type increases the accuracy of discriminating between patients and healthy controls. As well as being a validation of a theory-led prediction, these results offer promise for automated, enhanced and early diagnosis of Parkinson’s Disease.

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Item Type:	Article
Authors/Creators:	Bannard, C. Leriche, M. Bandmann, O. Brown, C.H. Ferracane, E. Sanchez-Ferro, A. Obeso, J. Redgrave, P. Stafford, T. https://orcid.org/0000-0002-8089-9479
Copyright, Publisher and Additional Information:	© The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Dates:	Accepted: 11 December 2018 Published (online): 4 March 2019 Published: 4 March 2019
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Faculty of Science (Sheffield) > Department of Psychology (Sheffield)
Funding Information:	Funder Grant number MICHAEL J FOX FOUNDATION 9877
Depositing User:	Symplectic Sheffield
Date Deposited:	11 Jan 2019 11:49
Last Modified:	20 Mar 2019 12:24
Status:	Published
Publisher:	Nature Research
Refereed:	Yes
Identification Number:	10.1038/s41598-019-39294-z
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:139911

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Reduced habit-driven errors in Parkinson’s Disease

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