Knights, OB orcid.org/0000-0003-1729-1492, Ye, S orcid.org/0000-0001-5152-5753, Ingram, N orcid.org/0000-0001-5274-8502 et al. (4 more authors) (2017) Optimising gold nanorod size for maximum photoacoustic response while minimising cell toxicity. In: Proceedings of Meetings on Acoustics. 173rd Meeting of Acoustical Society of America and 8th Forum Acusticum, 25-29 Jun 2017, Boston. Acoustical Society of America
Abstract
Plasmonic nanoparticles show great potential for molecular-targeted photoacoustic (PA) imaging. To maximise light absorption, the gold nanorods (AuNRs) are illuminated at their surface plasmon resonance (SPR), which for biomedical application is typically in the ’optical window’ of 700-900nm. For AuNRs, one of the main factors that determines the SPR is their aspect ratio. Since it is possible to have a similar aspect ratio, but different size of the particle the choice of particle could have a critical effect on a number of factors, such as, photoacoustic emissions, cell toxicity and therapeutic efficacy. For example, a particular sized AuNR may produce a higher PA response, for an equivalent laser fluence, but be more toxic to cell populations. In this study, the PA response of AuNRs with four different volumes but similar aspect ratios (∼4) are compared. A linear relationship between incident laser fluence and PA amplitude is shown and results indicate that AuNRs with larger volumes produce stronger PA emissions. In-vitro cell studies were performed on a lung cancer cell line to assess the cell toxicity of the different sized AuNRs via a colourmetric assay.
Metadata
Item Type: | Proceedings Paper |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | Copyright 2017 Acoustical Society of America. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the Acoustical Society of America. The following article appeared in Proc. Mtgs. Acoust. 30, 020001 (2017) and may be found at https://doi.org/10.1121/2.0000596 |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Electronic & Electrical Engineering (Leeds) > Robotics, Autonomous Systems & Sensing (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Physics and Astronomy (Leeds) > Molecular & Nanoscale Physics The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Molecular Gastroenterology (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Translational Medicine (Leeds) |
Funding Information: | Funder Grant number Leverhulme Trust ECF-2013-247 EPSRC EP/K503836/1 EPSRC EP/S001069/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 25 Oct 2018 11:14 |
Last Modified: | 13 Dec 2024 15:46 |
Status: | Published |
Publisher: | Acoustical Society of America |
Identification Number: | 10.1121/2.0000596 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:137705 |