Guex, A. G., Spicer, C. D. orcid.org/0000-0001-8787-578X, Armgarth, A. et al. (5 more authors) (2017) Electrospun aniline-tetramer-co-polycaprolactone fibers for conductive, biodegradable scaffolds. MRS Communications. pp. 375-382. ISSN 2159-6859
Abstract
Conjugated polymers have been proposed as promising materials for scaffolds in tissue engineering applications. However, the restricted processability and biodegradability of conjugated polymers limit their use for biomedical applications. Here we synthesized a block-co-polymer of aniline tetramer and PCL (AT-PCL), and processed it into fibrous non-woven scaffolds by electrospinning. We showed that fibronectin (Fn) adhesion was dependent on the AT-PCL oxidative state, with a reduced Fn unfolding length on doped membranes. Furthermore, we demonstrated the cytocompatibility and potential of these membranes to support the growth and osteogenic differentiation of MC3T3-E1 cells over 21 days.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © Materials Research Society 2017 |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) The University of York > Faculty of Sciences (York) > Electronic Engineering (York) |
Depositing User: | Pure (York) |
Date Deposited: | 07 Sep 2018 11:00 |
Last Modified: | 26 Nov 2024 00:39 |
Published Version: | https://doi.org/10.1557/mrc.2017.45 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1557/mrc.2017.45 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:135448 |
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