Grogan, Gideon orcid.org/0000-0003-1383-7056 (2018) Synthesis of chiral amines using redox biocatalysis. Current Opinion in Chemical Biology. pp. 15-22. ISSN 1367-5931
Abstract
Chiral amines feature in a large number of small molecule pharmaceuticals, and thus methods for their asymmetric synthesis are of considerable interest. Biocatalytic approaches have come to the fore in recent years as these offer advantages of superior atom economy, mild reaction conditions and excellent stereoselectivity. Advances in redox cofactor process technology have meant that oxidoreductase enzymes in particular now have growing potential as industrial catalysts for amine formation. In this review we survey recent developments in the discovery and application of oxidoreductase enzymes for amine production, including Monoamine Oxidases (MAOs), engineered and natural Amine Dehydrogenases (AmDHs), Imine Reductases (IREDs) and Reductive Aminases (RedAms), in addition to their application in enzyme cascades.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | Copyright © 2017. Published by Elsevier Ltd. |
Keywords: | Journal Article,Review |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 24 Jul 2018 23:36 |
Last Modified: | 02 Apr 2025 23:10 |
Published Version: | https://doi.org/10.1016/j.cbpa.2017.09.008 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1016/j.cbpa.2017.09.008 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:133770 |
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