Warren, PM, Dickens, SM, Gigout, S et al. (2 more authors) (2018) Regulation of CNS plasticity through the extracellular matrix. In: Chao, MV, (ed.) The Oxford Handbook of Developmental Neural Plasticity. Oxford handbooks online . Oxford University Press , New York, USA ISBN 9780190635374
Abstract
Contrary to established dogma, the central nervous system (CNS) has a capacity for regeneration and is moderately plastic. Traditionally, such changes have been recognized through development, but more recently, this has been documented in adults through learning and memory or during the advent of trauma and disease. One of the causes of such plasticity has been related to changes in the extracellular matrix (ECM). This complex scaffold of sugars and proteins in the extracellular space alters functionality of the surrounding tissue through moderation of synaptic connections, neurotransmission, ion diffusion, and modification to the cytoskeleton. This chapter discusses the role of the ECM in CNS plasticity in development and the adult. Further, it determines how the ECM affects normal neuronal functioning in critical processes such as memory. Finally, the chapter assesses how the ECM contributes to adverse CNS changes in injury and disease, concentrating on how this matrix may be targeted for therapeutic intervention.
Metadata
Item Type: | Book Section |
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Authors/Creators: |
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Editors: |
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Copyright, Publisher and Additional Information: | © Oxford University Press, 2018. This is an author produced version of a book chapter published in The Oxford Handbook of Developmental Neural Plasticity. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | perineuronal nets; chondroitin sulfate; extracellular matrix; plasticity; development and aging; neuronal excitability; CNS disorders and injury |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 01 May 2018 11:01 |
Last Modified: | 10 Oct 2020 00:38 |
Status: | Published online |
Publisher: | Oxford University Press |
Series Name: | Oxford handbooks online |
Identification Number: | 10.1093/oxfordhb/9780190635374.013.11 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:130251 |