Harris, Sam, Ma, Hongtao, Zhao, Mingrui et al. (7 more authors) (2014) Coupling between gamma-band power and cerebral blood volume during recurrent acute neocortical seizures. Neuroimage. pp. 62-70. ISSN 1053-8119
Abstract
Characterization of neural and hemodynamic biomarkers of epileptic activity that can be measured using non-invasive techniques is fundamental to the accurate identification of the epileptogenic zone (EZ) in the clinical setting. Recently, oscillations at gamma-band frequencies and above (>30 Hz) have been suggested to provide valuable localizing information of the EZ and track cortical activation associated with epileptogenic processes. Although a tight coupling between gamma-band activity and hemodynamic-based signals has been consistently demonstrated in non-pathological conditions, very little is known about whether such a relationship is maintained in epilepsy and the laminar etiology of these signals. Confirmation of this relationship may elucidate the underpinnings of perfusion-based signals in epilepsy and the potential value of localizing the EZ using hemodynamic correlates of pathological rhythms. Here, we use concurrent multi-depth electrophysiology and 2-dimensional optical imaging spectroscopy to examine the coupling between multi-band neural activity and cerebral blood volume (CBV) during recurrent acute focal neocortical seizures in the urethane-anesthetized rat. We show a powerful correlation between gamma-band power (25-90 Hz) and CBV across cortical laminae, in particular layer 5, and a close association between gamma measures and multi-unit activity (MUA). Our findings provide insights into the laminar electrophysiological basis of perfusion-based imaging signals in the epileptic state and may have implications for further research using non-invasive multi-modal techniques to localize epileptogenic tissue.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | Copyright © 2014. Published by Elsevier Inc. |
Keywords: | 4-Aminopyridine,Animals,Blood Volume,Cerebrovascular Circulation,Convulsants,Electroencephalography,Female,Gamma Rhythm,Neocortex,Optical Imaging,Rats,Recurrence,Seizures,Journal Article,Research Support, Non-U.S. Gov't |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 02 Feb 2018 09:50 |
Last Modified: | 21 Jan 2025 17:30 |
Published Version: | https://doi.org/10.1016/j.neuroimage.2014.04.014 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1016/j.neuroimage.2014.04.014 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:126986 |
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