Almodares, Z, Lucas, SJ, Crossley, BD et al. (5 more authors) (2014) Rhodium, Iridium, and Ruthenium Half-Sandwich Picolinamide Complexes as Anticancer Agents. Inorganic Chemistry, 53 (2). pp. 727-736. ISSN 0020-1669
Abstract
Novel rhodium, iridium, and ruthenium half-sandwich complexes containing (N,N)-bound picolinamide ligands have been prepared for use as anticancer agents. The complexes show promising cytotoxicities, with the presence, position, and number of halides having a significant effect on the corresponding IC50 values. One ruthenium complex was found to be more cytotoxic than cisplatin on HT-29 and MCF-7 cells after 5 days and 1 h, respectively, and it remains active with MCF-7 cells even under hypoxic conditions, making it a promising candidate for in vivo studies.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | copyright (c) 2014 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Inorganic Chemistry after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/ic401529u |
Keywords: | Amides; Antineoplastic Agents; Cell Hypoxia; HT29 Cells; Humans; Inhibitory Concentration 50; Iridium; MCF-7 Cells; Organometallic Compounds; Picolinic Acids; Rhodium; Ruthenium |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Inorganic Chemistry (Leeds) The University of Leeds > Faculty of Arts, Humanities and Cultures (Leeds) > School of Design (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 12 Mar 2018 11:12 |
Last Modified: | 21 Mar 2018 13:20 |
Status: | Published |
Publisher: | American Chemical Society |
Identification Number: | 10.1021/ic401529u |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:126829 |