El-Jawhari, JJ orcid.org/0000-0002-0580-4492, Brockett, CL orcid.org/0000-0002-6664-7259, Ktistakis, I et al. (2 more authors) (2018) The regenerative therapies of the ankle degeneration; A focus on multipotential mesenchymal stromal cell application. Regenerative Medicine, 13 (2). pp. 175-188. ISSN 1746-0751
Abstract
The ankle degeneration ranging from focal osteochondral lesions to osteoarthritis (OA) can cause a total joint function loss. With rising life-expectancy and activity of the patients, various regenerative therapies were introduced aiming to preserve the joint function via the induction of cartilage and bone repair. Here, biological events and mechanical changes of the ankle degeneration were discussed. The regenerative therapies were reviewed versus the standard surgical treatment. We especially focused on the use of multipotential mesenchymal stromal cells (MSCs) highlighting their dual functions of regeneration and cell modulation with the focus on the emerging MSC-based clinical studies. Being at an early step, more basic and clinical research is needed to optimize the applications of all ankle regenerative therapies including MSC-based method.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This is an author produced version of a paper published in Regenerative medicine. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | ankle, bone, cartilage, cell therapy, mesenchymal (multipotential) stromal cells, osteoarthritis, osteochondral lesion, regeneration |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Mechanical Engineering (Leeds) > Institute of Medical and Biological Engineering (iMBE) (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) > Orthopaedics (Leeds) |
Funding Information: | Funder Grant number Biomet Biologics NAD no. BIO.CR.BIO001 AO Foundation S-16-132E Stryker Biotech LLC NO EXT REF GIVEN |
Depositing User: | Symplectic Publications |
Date Deposited: | 15 Jan 2018 15:05 |
Last Modified: | 19 Mar 2019 01:38 |
Status: | Published |
Publisher: | Future Medicine |
Identification Number: | 10.2217/rme-2017-0104 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:126189 |