Using 2H Labelling to Improve the NMR detectability of a Series of Pyridines by SABRE

Abstract

By introducing a range of 2H labels into pyridine and the para-substituted agents methyl isonicotinate and isonicotinamide we significantly improve their NMR detectability in conjunction with the Signal Amplification by Reversible Exchange (SABRE) process. We describe how the rates of T1 relaxation for the remaining 1H nuclei are increased and show how this leads to a concomitant increase in the level of 1H and 13C hyperpolarization that can ultimately be detected.

Metadata

Item Type:	Article
Authors/Creators:	Norcott, Philip https://orcid.org/0000-0003-4082-2079 Burns, Michael J. https://orcid.org/0000-0002-5569-1270 Rayner, Peter J. https://orcid.org/0000-0002-6577-4117 Mewis, Ryan E. (rem505@york.ac.uk) Duckett, Simon B. https://orcid.org/0000-0002-9788-6615
Copyright, Publisher and Additional Information:	.This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details
Dates:	Accepted: 10 December 2017 Published (online): 25 January 2018
Institution:	The University of York
Academic Units:	The University of York The University of York > Faculty of Sciences (York) > Chemistry (York)
Funding Information:	Funder Grant number WELLCOME TRUST 098335/Z/12/Z
Depositing User:	Pure (York)
Date Deposited:	03 Jan 2018 10:20
Last Modified:	10 Apr 2025 23:15
Published Version:	https://doi.org/10.1002/mrc.4703
Status:	Published online
Refereed:	Yes
Identification Number:	10.1002/mrc.4703
Related URLs:	http://www.scopus.com/inward/record.url?...
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:125745