Manoharan, Anand, Rayner, Peter J. orcid.org/0000-0002-6577-4117, Iali, Wissam orcid.org/0000-0002-9428-2023 et al. (3 more authors) (2017) Achieving Biocompatible SABRE:An in vitro Cytotoxicity Study. ChemMedChem. ISSN 1860-7187
Abstract
Production of a biocompatible hyperpolarized bolus for signal amplification by reversible exchange (SABRE) could open the door to simple clinical diagnosis via magnetic resonance imaging. Essential to successful progression to preclinical/clinical applications is the determination of the toxicology profile of the SABRE reaction mixture. Herein, we exemplify the cytotoxicity of the SABRE approach using invitro cell assays. We conclude that the main cause of the observed toxicity is due to the SABRE catalyst. We therefore illustrate two catalyst removal methods: one involving deactivation and ion-exchange chromatography, and the second using biphasic catalysis. These routes produce a bolus suitable for future invivo study.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018, The Authors. |
Keywords: | Biocompatibility,Biphasic catalysis,Cytotoxicity,Hyperpolarization,SABRE |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York The University of York > Faculty of Sciences (York) > Chemistry (York) |
Funding Information: | Funder Grant number WELLCOME TRUST 098335/Z/12/Z |
Depositing User: | Pure (York) |
Date Deposited: | 13 Dec 2017 10:40 |
Last Modified: | 27 Nov 2024 00:31 |
Published Version: | https://doi.org/10.1002/cmdc.201700725 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1002/cmdc.201700725 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:125215 |
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Licence: CC-BY 2.5