Ashauer, Roman orcid.org/0000-0002-9579-8793 and Jager, Tjalling (2017) Physiological modes of action across species and toxicants:the key to predictive ecotoxicology. Environmental Sciences: Processes and Impacts. 10.1039/c7em00328e. pp. 48-57. ISSN 2050-7895
Abstract
As ecotoxicologists we strive for a better understanding of how chemicals affect our environment. Humanity needs tools to identify those combinations of man-made chemicals and organisms most likely to cause problems. In other words: which of the millions of species are at risk from pollution? And which of the tens of thousands of chemicals contribute most to the risk? We identified our poor knowledge on physiological modes of action (how a chemical affects the energy allocation in an organism), and how they vary across species and toxicants, as a major knowledge gap. We also find that the key to predictive ecotoxicology is the systematic, rigorous characterization of physiological modes of action because that will enable more powerful in vitro to in vivo toxicity extrapolation and in silico ecotoxicology. In the near future, we expect a step change in our ability to study physiological modes of action by improved, and partially automated, experimental methods. Once we have populated the matrix of species and toxicants with sufficient physiological mode of action data we can look for patterns, and from those patterns infer general rules, theory and models.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Environment and Geography (York) |
Funding Information: | Funder Grant number EUROPEAN COMMISSION UNSPECIFIED |
Depositing User: | Pure (York) |
Date Deposited: | 09 Nov 2017 14:19 |
Last Modified: | 07 Feb 2025 00:18 |
Published Version: | https://doi.org/10.1039/C7EM00328E |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1039/C7EM00328E |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:123818 |
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Description: Physiological modes of action across species and toxicants: the key to predictive ecotoxicology
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