Gray, L.A. orcid.org/0000-0001-6365-7710, Hernandez Alava, M. orcid.org/0000-0003-4474-5883 and Wailoo, A.J. orcid.org/0000-0002-9324-1617 (2018) Development of methods for the mapping of utilities using mixture models: Mapping the AQLQ-S to EQ-5D-5L and HUI3 in patients with asthma. Value in Health, 21 (6). pp. 748-757. ISSN 1098-3015
Abstract
Objectives To develop these methods in different ways and to compare performance in a case study. Methods Data from 856 patients with asthma allowed mapping between the Asthma Quality of Life Questionnaire and both the five-level EuroQol five-dimensional questionnaire (EQ-5D-5L) and the health utilities index mark 3 (HUI3). Adjusted limited dependent variable mixture models and beta-based mixture models were estimated. Optional inclusion of the gap between full health and the next value as well as a mass point at the next feasible value were explored. Results In all cases, model specifications formally modeling the gap between full health and the next feasible value were an improvement on those that did not. Mapping to the HUI3 required more components in the mixture models than did mapping to the EQ-5D-5L because of its uneven distribution. The optimal beta-based mixture models mapping to the HUI3 included a probability mass at the utility value adjacent to full health. This is not the case when estimating the EQ-5D-5L, because of the low proportion of observations at this point. Conclusions Beta-based mixture models marginally outperformed adjusted limited dependent variable mixture models with the same number of components in this data set. Nevertheless, they require a larger number of parameters and longer estimation time. Both mixture model types closely fit both EQ-5D-5L and HUI data. Standard mapping approaches typically lead to biased estimates of health gain. The mixture model approaches exhibit no such bias. Both can be used with confidence in applied cost-effectiveness studies. Future mapping studies in other disease areas should consider similar methods.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018, International Society for Pharmacoeconomics and Outcomes Research (ISPOR). This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | mapping; EQ5D; HUI; utility |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > ScHARR - Sheffield Centre for Health and Related Research |
Funding Information: | Funder Grant number MEDICAL RESEARCH COUNCIL MR/L022575/1 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 26 Oct 2017 11:07 |
Last Modified: | 22 Dec 2023 11:44 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.jval.2017.09.017 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:123056 |