Stephens, Thomas C, Lodi, Mahendar, Steer, Andrew M et al. (3 more authors) (2017) Synthesis of cyclic peptide mimetics via the successive ring expansion of lactams. Chemistry : A European Journal. pp. 13314-13318. ISSN 1521-3765
Abstract
A successive ring expansion protocol is reported that enables the controlled insertion of natural and non-natural amino acid fragments into lactams. Amino acids can be installed into macrocycles via an operationally simple and scalable iterative procedure, without the need for high dilution. This method is expected to be of broad utility, especially for the synthesis of medicinally important cyclic peptide mimetics.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details |
Keywords: | Journal Article,cyclic peptides,lactams,medium-sized rings,macrocycles,ring expansion,Cyclization,Amino Acids/chemistry,Peptoids/chemical synthesis,Molecular Conformation,Lactams/chemistry,Peptides, Cyclic/chemistry |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 27 Jul 2017 09:45 |
Last Modified: | 10 Dec 2024 00:13 |
Published Version: | https://doi.org/10.1002/chem.201703316 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1002/chem.201703316 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:119580 |
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Filename: SuRE_lactam_paper_accepted_manuscript.docx
Description: SuRE lactam paper accepted manuscript