Price, DJ, Khuphe, M orcid.org/0000-0002-6289-8675, Davies, RPW orcid.org/0000-0002-9135-9320 et al. (3 more authors) (2017) Poly(amino acid)-polyester graft copolymer nanoparticles for the acid-mediated release of doxorubicin. Chemical Communications, 53 (62). pp. 8687-8690. ISSN 1359-7345
Abstract
Biodegradable polymers have emerged as highly effective drug delivery vehicles. We combine N-carboxyanhydride and O-carboxyanhydride ring opening polymerisations to synthesise a poly(amino acid)-polyester graft copolymer capable of encapsulating, and subsequently releasing
doxorubicin via acid-mediated hydrolysis. Consequently, the nanoparticles detailed are extremely promising vehicles for the controlled delivery of chemotherapeutic agents.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Royal Society of Chemistry 2017. This is an author produced version of a paper published in Chemical Communications. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Colour Science (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Electronic & Electrical Engineering (Leeds) > Robotics, Autonomous Systems & Sensing (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > Oral Biology (Leeds) |
Funding Information: | Funder Grant number Innovate UK - KTP fkaTechnology Strategy Board (KTP) 509151 Royal Society of Chemistry Not Known National Printing Bureau of Japan n/a Royal Society of Chemistry Not Known |
Depositing User: | Symplectic Publications |
Date Deposited: | 17 Jul 2017 15:54 |
Last Modified: | 20 Jun 2021 08:37 |
Status: | Published |
Publisher: | Royal Society of Chemistry |
Identification Number: | 10.1039/C7CC04504B |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:119041 |