Mancuso, E orcid.org/0000-0003-1742-1656, Bretcanu, O, Marshall, M et al. (1 more author) (2017) Sensitivity of novel silicate and borate-based glass structures on in vitro bioactivity and degradation behaviour. Ceramics International, 43 (15). pp. 12651-12657. ISSN 1873-3956
Abstract
Three novel glass compositions, identified as NCL2 (SiO₂-based), NCL4 (B₂O₃-based) and NCL7 (SiO₂-based), along with apatite-wollastonite (AW) were processed to form sintered dense pellets, and subsequently evaluated for their in vitro bioactive potential, resulting physico-chemical properties and degradation rate. Microstructural analysis showed the carbonated hydroxyapatite (HCA) precipitate morphology following SBF testing to be composition-dependent. AW and the NCL7 formulation exhibited greater HCA precursor formation than the NCL2 and NCL4-derived pellets. Moreover, the NCL4 borate-based samples showed the highest biodegradation rate; with silicate-derived structures displaying the lowest weight loss after SBF immersion. The results of this study suggested that glass composition has significant influence on apatite-forming ability and also degradation rate, indicating the possibility to customise the properties of this class of materials towards the bone repair and regeneration process.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Editors: |
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Copyright, Publisher and Additional Information: | © 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/). |
Keywords: | bioceramics; bioactivity; degradation; apatite formation. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Mechanical Engineering (Leeds) > Institute of Functional Surfaces (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 26 Jun 2017 11:34 |
Last Modified: | 23 Jun 2023 22:31 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.ceramint.2017.06.146 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:118207 |