Daniel, E. orcid.org/0000-0003-4699-420X and Newell-Price, J. (2017) Recent advances in understanding Cushing disease: resistance to glucocorticoid negative feedback and somatic USP8 mutations. F1000Research, 6. p. 613. ISSN 2046-1402
Abstract
Cushing’s disease is a rare disease with a characteristic phenotype due to significant hypercortisolism driven by over-secretion of adrenocorticotropic hormone and to high morbidity and mortality if untreated. It is caused by a corticotroph adenoma of the pituitary, but the exact mechanisms leading to tumorigenesis are not clear. Recent advances in molecular biology such as the discovery of somatic mutations of the ubiquitin-specific peptidase 8 (USP8) gene allow new insights into the pathogenesis, which could be translated into exciting and much-needed therapeutic applications.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Daniel E and Newell-Price J. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield) The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 29 Jun 2017 15:56 |
Last Modified: | 29 Jun 2017 15:56 |
Published Version: | https://doi.org/10.12688/f1000research.10968.1 |
Status: | Published |
Publisher: | F1000Research |
Refereed: | Yes |
Identification Number: | 10.12688/f1000research.10968.1 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:118019 |