Leese, Henry J, Guerif, Fabrice, Allgar, Victoria orcid.org/0000-0002-5228-2623 et al. (3 more authors) (2016) Biological optimization, the Goldilocks principle, and how much is lagom in the preimplantation embryo. Molecular Reproduction and Development. pp. 748-754. ISSN 1040-452X
Abstract
The quiet embryo hypothesis postulates that early embryo viability is associated with a relatively low metabolism (Leese, 2002 BioEssays 24: 845-849). This proposal is re-visited here using retrospective and prospective data on the metabolic activity and kinetics of preimplantation development alongside the concept that an optimal range of such indices and of energetic efficiency influences embryogenesis. It is concluded that these considerations may be rationalized by proposing the existence of a "Goldilocks zone," or as it is known in Sweden, of lagom-meaning "just the right amount"-within which embryos with maximum developmental potential can be categorized. Mol. Reprod. Dev. 83: 748-754, 2016 © 2016 Wiley Periodicals, Inc.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 Wiley Periodicals, Inc. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details |
Keywords: | Journal Article |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Biology (York) The University of York > Faculty of Sciences (York) > Hull York Medical School (York) |
Depositing User: | Pure (York) |
Date Deposited: | 07 Jun 2017 11:30 |
Last Modified: | 16 Oct 2024 13:49 |
Published Version: | https://doi.org/10.1002/mrd.22684 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1002/mrd.22684 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:117470 |
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