Georgiou, L, Sharma, N, Broadbent, DA et al. (4 more authors) (2018) Estimating breast tumor blood flow during neoadjuvant chemotherapy using interleaved high temporal and high spatial resolution MRI. Magnetic Resonance in Medicine, 79 (1). pp. 317-326. ISSN 0740-3194
Abstract
Purpose: To evaluate an interleaved MRI sampling strategy that acquires both high temporal resolution (HTR) dynamic contrast-enhanced (DCE) data for quantifying breast tumor blood flow (TBF) and high spatial resolution (HSR) DCE data for clinical reporting, following a single standard injection of contrast agent. Methods: A simulation study was used to evaluate the performance of the interleaved technique under different conditions. In a prospective clinical study, 18 patients with primary breast cancer, who were due to undergo neoadjuvant chemotherapy (NACT), were examined using interleaved HTR and HSR DCE-MRI at 1.5 Tesla. Tumor regions of interest were analyzed with a two-compartment tracer kinetic model. Paired parameters (n = 10) from the data acquired before and post–cycle 2 of NACT were compared using the nonparametric Wilcoxon signed-rank test. Results: Simulations demonstrated that TBF was reliably estimated using the proposed strategy. The region of interest analysis revealed significant changes in TBF (0.81–0.43 mL/min/mL; P = 0.002) following two cycles of NACT. The HSR data were reported in the normal way and enabled the assessment of tumor volume, which decreased by 53% following NACT (P = 0.065). Conclusions: TBF can be measured reliably using the proposed strategy without compromising a standard clinical protocol. Furthermore, in our feasibility study, TBF decreased significantly following NACT, whereas capillary permeability surface-area product did not.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 International Society for Magnetic Resonance in Medicine. This is the peer reviewed version of the following article: 'Georgiou, L., Sharma, N., Broadbent, D. A., Wilson, D. J., Dall, B. J., Gangi, A. and Buckley, D. L. (2018). Estimating breast tumor blood flow during neoadjuvant chemotherapy using interleaved high temporal and high spatial resolution MRI. Magnetic Resonance in Medicine, 79 (1). pp. 317-326,' which has been published in final form at https://doi.org/10.1002/mrm.26684. This article may be used for non-commercial purposes in accordance with the Wiley Terms and Conditions for Self-Archiving. |
Keywords: | DCE-MRI; tracer kinetic model; breast; tumor blood flow; chemotherapy; high temporal resolution |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 23 May 2017 13:14 |
Last Modified: | 03 Apr 2018 00:39 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/mrm.26684 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:116822 |