Sanli, O, Dobruch,, J, Knowles, MA orcid.org/0000-0002-9363-8657 et al. (4 more authors) (2017) Bladder Cancer. Nature Reviews Disease Primers, 3. 17022. ISSN 2056-676X
Abstract
Bladder cancer is a highly prevalent disease associated with substantial morbidity, mortality and cost. Environmental or occupational exposures to carcinogens, and especially tobacco, are the main risk factors for bladder cancer. Most bladder cancers are diagnosed after patients complain of macroscopic haematuria, and cases are confirmed after transurethral resection of bladder tumour (TURBT), which also serves as the first stage of treatment. Bladder cancer develops via two distinct pathways, giving rise to non-muscle-invasive papillary tumours and non-papillary (solid) muscle-invasive tumours. Both subtypes have unique pathological features and different molecular characteristics. Indeed, The Cancer Genome Atlas project identified genetic drivers of muscle-invasive bladder cancer (MIBC) as well as subtypes of MIBC with unique characteristics and therapeutic responses. For non-muscle-invasive bladder cancer (NMIBC), intravesical therapies (primarily Bacillus Calmette–Guérin (BCG)) with maintenance are the main treatments to prevent recurrence and progression after initial TURBT; additional therapies are needed for those who do not respond to BCG. For localized MIBC, optimizing care is important as is the goal to reduce morbidity of removing the bladder. In metastatic disease, advancements in genetic understanding and immunotherapy are being translated into novel therapies.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Macmillan Publishers Limited, part of Springer Nature. This is an author produced version of a paper published in Nature Reviews Disease Primers. Uploaded in accordance with the publisher's self-archiving policy. The final publication is available at https://doi.org/10.1038/nrdp.2017.22. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 08 Mar 2017 15:51 |
Last Modified: | 03 Nov 2017 13:28 |
Published Version: | https://doi.org/10.1038/nrdp.2017.22 |
Status: | Published |
Publisher: | Nature Publishing Group |
Identification Number: | 10.1038/nrdp.2017.22 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:113339 |