Bean, Thomas George, Arnold, Kathryn Elizabeth orcid.org/0000-0002-6485-6065, Lane, Julie et al. (4 more authors) (2017) Predictive framework for estimating exposure of birds to pharmaceuticals. Environmental Toxicology and Chemistry. ISSN 1552-8618
Abstract
Here we present and evaluate a framework for estimating concentrations of pharmaceuticals over time in wildlife feeding at wastewater treatment plants (WWTPs). The framework is composed of a series of predictive steps involving the estimation of pharmaceutical concentration in wastewater, accumulation into wildlife food items, uptake by wildlife with subsequent distribution into, and elimination from, tissues. As many pharmacokinetic parameters for wildlife are unavailable for the majority of drugs in use, a read-across approach was employed using either rodent or human data on absorption, distribution, metabolism and excretion (ADME). Comparison of the different steps in the framework, against experimental data for the scenario where birds are feeding on a WWTP contaminated with fluoxetine, showed that: estimated concentrations in wastewater treatment works were lower than measured concentrations; concentrations in food could be reasonably estimated if experimental bioaccumulation data are available; and that read-across from rodent data worked better than human to bird read-across. The framework provides adequate predictions of plasma concentrations and of elimination behavior in birds, but yields poor predictions of distribution in tissues. We believe the approach holds promise, but it is important that we improve our understanding of the physiological similarities and differences between wild birds and domesticated laboratory mammals used in pharmaceutical efficacy/safety trials, so that the wealth of data available can be applied more effectively in ecological risk assessments.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details |
Keywords: | Read-across, Ecological Risk Assessment, Fluoxetine, Pharmacokinetics, Wild birds |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Environment and Geography (York) The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 17 Feb 2017 09:20 |
Last Modified: | 28 Jan 2025 00:06 |
Published Version: | https://doi.org/10.1002/etc.3771 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1002/etc.3771 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:112481 |
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