Petersen, Wade F, Taylor, Richard J K orcid.org/0000-0002-5880-2490 and Donald, James R orcid.org/0000-0002-2176-4902 (2017) Photoredox-Catalyzed Reductive Carbamoyl Radical Generation:A Redox-Neutral Intermolecular Addition-Cyclization Approach to Functionalized 3,4-Dihydroquinolin-2-ones. Organic Letters. ISSN 1523-7052
Abstract
The first reductive generation of carbamoyl radicals using photoredox catalysis for their formation is reported. This approach facilitated the development of a redox-neutral synthesis of functionalized 3,4-dihydroquinolin-2-ones via the novel intermolecular addition-cyclization of carbamoyl radicals across electron-deficient alkenes. To illustrate the versatility of this reaction, a diverse collection of 3,4-dihydroquinolin-2-ones, including fused cyclic and spirocyclic systems inspired by natural products, has been prepared.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017, American Chemical Society. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 08 Feb 2017 07:35 |
Last Modified: | 17 Dec 2024 00:07 |
Published Version: | https://doi.org/10.1021/acs.orglett.7b00022 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1021/acs.orglett.7b00022 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:111998 |
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