Capel, AJ, Wright, A, Harding, MJ et al. (6 more authors) (2017) 3D printed fluidics with embedded analytic functionality for automated reaction optimisation. Beilstein Journal of Organic Chemistry, 13. pp. 111-119. ISSN 1860-5397
Abstract
Additive manufacturing or ‘3D printing’ is being developed as a novel manufacturing process for the production of bespoke micro and milli-scale fluidic devices. When coupled with online monitoring and optimisation software, this offers an advanced, customised method for performing automated chemical synthesis. This paper reports the use of two additive manufacturing processes, stereolithography and selective laser melting, to create multi-functional fluidic devices with embedded reaction monitoring capability. The selectively laser melted parts are the first published examples of multi-functional 3D printed metal fluidic devices. These devices allow high temperature and pressure chemistry to be performed in solvent systems destructive to the majority of devices manufactured via the stereolithography, polymer jetting and fused deposition modelling processes previously utilised for this application. These devices were integrated with commercially available flow chemistry, chromatographic and spectroscopic analysis equipment, allowing automated online and inline optimisation of the reaction medium. This setup allowed the optimisation of two reactions, a ketone functional group inter-conversion and a fused polycyclic heterocycle formation, via spectroscopic and chromatographic analysis.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Capel et al.; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc) |
Keywords: | 3D Printing; Inline Reaction Analysis; Reaction Optimisation; Selective Laser Melting; Stereolithography |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Mechanical Engineering (Leeds) > Institute of Medical and Biological Engineering (iMBE) (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 22 Feb 2017 09:26 |
Last Modified: | 23 Jun 2023 22:21 |
Published Version: | https://doi.org/10.3762/bjoc.13.14 |
Status: | Published |
Publisher: | Beilstein-Institut |
Identification Number: | 10.3762/bjoc.13.14 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:111175 |