Luna, E., van Hulten, M., Zhang, Y. et al. (10 more authors) (2014) Plant perception of beta-aminobutyric acid is mediated by an aspartyl-tRNA synthetase. Nature Chemical Biology, 10 (6). pp. 450-456. ISSN 1552-4450
Abstract
Specific chemicals can prime the plant immune system for augmented defense. β-aminobutyric acid (BABA) is a priming agent that provides broad-spectrum disease protection. However, BABA also suppresses plant growth when applied in high doses, which has hampered its application as a crop defense activator. Here we describe a mutant of Arabidopsis thaliana that is impaired in BABA-induced disease immunity (ibi1) but is hypersensitive to BABA-induced growth repression. IBI1 encodes an aspartyl-tRNA synthetase. Enantiomer-specific binding of the R enantiomer of BABA to IBI1 primed the protein for noncanonical defense signaling in the cytoplasm after pathogen attack. This priming was associated with aspartic acid accumulation and tRNA-induced phosphorylation of translation initiation factor eIF2α. However, mutation of eIF2α-phosphorylating GCN2 kinase did not affect BABA-induced immunity but relieved BABA-induced growth repression. Hence, BABA-activated IBI1 controls plant immunity and growth via separate pathways. Our results open new opportunities to separate broad-spectrum disease resistance from the associated costs on plant growth.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2014 Nature America, Inc. This is an author produced version of a paper subsequently published in Nature Chemical Biology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Genetics; Plant hormones; Plant signalling; Small molecules |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Animal and Plant Sciences (Sheffield) The University of Sheffield > Faculty of Science (Sheffield) > Department of Chemistry (Sheffield) |
Funding Information: | Funder Grant number EUROPEAN RESEARCH COUNCIL PRIME-A-PLANT - 309944 LEVERHULME TRUST (THE) RL-2012-042 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 01 Mar 2017 16:36 |
Last Modified: | 27 Mar 2018 15:54 |
Published Version: | https://doi.org/10.1038/NCHEMBIO.1520 |
Status: | Published |
Publisher: | Nature Publishing Group |
Refereed: | Yes |
Identification Number: | 10.1038/NCHEMBIO.1520 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:110817 |