Osorio, J.G., Sayin, R., Kalbag, A.V. et al. (4 more authors) (2016) Scaling of continuous twin screw wet granulation. AIChE Journal. ISSN 0001-1541
Abstract
Scaling rules were developed and tested for a continuous twin screw wet granulation process using three scales (11, 16, and 24 mm barrel diameter) of twin screw granulators (TSG). The distributive feed screw configuration used produced high porosity granules (50-60%) with broad bimodal size distributions, especially in the 16 and 24 mm TSGs. Three dimensionless numbers, Froude number (Fr), liquid-to-solid ratio (LSR), and powder feed number (PFN), were identified and their effect on granule size distribution (GSD), porosity and liquid distribution tested. Granule size increased with increasing LSR as expected. However, Fr and PFN had no significant effect on d10 or d50 and only a small effect on d90. In contrast, granulator scale had a strong effect on GSD, with d90 increasing almost linearly with barrel diameter. This is consistent with breakage of large granules being a dominant mechanism and directly controlled by the geometry of the screw.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 Wiley. This is the peer reviewed version of the following article: [Osorio, Juan G., et al. "Scaling of continuous twin screw wet granulation." AIChE Journal (2016).], which has been published in final form at [https://doi.org/10.1002/aic.15459 ]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
Keywords: | twin screw granulation; continuous manufacturing; powders; scaling |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Chemical and Biological Engineering (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 05 Jan 2017 10:28 |
Last Modified: | 21 Aug 2017 16:00 |
Published Version: | https://doi.org/10.1002/aic.15459 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1002/aic.15459 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:110026 |