Tronci, G orcid.org/0000-0002-9426-4220, Buiga, P, Alhilou, A et al. (3 more authors) (2017) Hydrolytic and lysozymic degradability of chitosan systems with heparin-mimicking pendant groups. Materials Letters, 188. pp. 359-363. ISSN 0167-577X
Abstract
Chitosan (CT) is an antibacterial polysaccharide that has been investigated for drug carriers, haemostats and wound dressings. For these applications, customised CT devices can often be obtained with specific experimental conditions, which can irreversibly alter native biopolymer properties and functions and lead to unreliable material behaviour. In order to investigate the structure-function relationships in CT covalent networks, monosodium 5 sulfoisophthalate (PhS) was selected as heparin-mimicking, growth factor-binding crosslinking segment, whilst 1,4 phenylenediacetic acid (4Ph) and poly(ethylene glycol) bis(carboxymethyl) ether (PEG) were employed as sulfonic acid-free diacids of low and high crosslinker length respectively. Hydrogels based on short crosslinkers (PhS and 4Ph) displayed increased crosslink density, decreased swelling ratio as well as minimal hydrolytic and lysozymic degradation, whilst addition of lysozymes to PEG based networks resulted in 70 wt.-% mass loss. PhS-crosslinked CT hydrogels displayed the highest loss (40 ± 6 CFU%) of antibacterial activity upon incubation with Porphyromonas gingivalis, whilst respective extracts were tolerated by L929 mouse fibroblasts.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 Published by Elsevier B.V. This is an author produced version of a paper published in Materials Letters. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | chitosan; biomaterial; functional; structure-function relationship |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > Oral Biology (Leeds) The University of Leeds > Faculty of Arts, Humanities and Cultures (Leeds) > School of Design (Leeds) |
Funding Information: | Funder Grant number ***Use 602393*** GB Sasakawa Found B67 Clothworkers ANDREW BLESSLEY |
Depositing User: | Symplectic Publications |
Date Deposited: | 29 Nov 2016 11:26 |
Last Modified: | 01 Dec 2017 01:38 |
Published Version: | https://doi.org/10.1016/j.matlet.2016.11.109 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.matlet.2016.11.109 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:108553 |