McKenzie, L., Sazanovich, I., Baggaley, E. et al. (5 more authors) (2016) Metal Complexes For Two-photon Photodynamic Therapy: A Cyclometallated Iridium Complex Induces Two-photon Photosensitization of Cancer Cells Under Near-IR Light. Chemistry - A European Journal. ISSN 0947-6539
Abstract
Photodynamic therapy (PDT) uses photosensitizers (PS) which only become cytotoxic upon light-irradiation. Transition metal complexes are highly promising PS due to long excited state lifetimes, and photostability. However, these complexes usually absorb higher-energy UV/Visible light, whilst the optimal tissue transparency is in the lower-energy NIR region. Two-photon excitation (TPE) can overcome this dichotomy, with simultaneous absorption of two lower-energy NIR-photons populating the same PS-active excited state as one higher-energy photon. We introduce two low-molecular weight, long-lived and photostable iridium complexes of the [Ir(N^C)2(N^N)]+ family with high TP-absorption, which localise to mitochondria and lysosomal structures in live cells. The compounds are efficient PS under 1-photon irradiation (405 nm) resulting in apoptotic cell death in diverse cancer cell lines at low light doses (3.6 J cm-2), low concentrations, and photoindexes of up to >555. Remarkably 1 also displays high PS activity killing cancer cells under NIR two-photon excitation (760 nm), which along with its photostability indicates potential future clinical application.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 Wiley. This is an author produced version of a paper subsequently published in Chemistry - A European Journal. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Singlet oxygen; cancer therapy; iridium; photodynamic therapy; two-photon excitation |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield) The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 02 Nov 2016 16:15 |
Last Modified: | 02 Nov 2017 19:12 |
Published Version: | http://doi.org/10.1002/chem.201604792 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1002/chem.201604792 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:106889 |