Duval, C orcid.org/0000-0002-4870-6542 and Ariëns, RAS orcid.org/0000-0002-6310-5745 (2017) Fibrinogen splice variation and cross-linking: Effects on fibrin structure/function and role of fibrinogen γ’ as thrombomobulin II. Matrix Biology, 60-61. pp. 8-15. ISSN 0945-053X
Abstract
Fibrin is an important matrix protein that provides the backbone to the blood clot, promoting tissue repair and wound healing. Its precursor fibrinogen is one of the most heterogenous proteins, with an estimated 1 million different forms due to alterations in glycosylation, oxidation, single nucleotide polymorphisms, splice variation and other variations. Furthermore, ligation by transglutamimase factor XIII (cross-linking) adds to the complexity of the fibrin network. The structure and function of the fibrin network is in part determined by this natural variation in the fibrinogen molecule, with major effects from slice variation and cross-linking. This mini-review will discuss the direct effects of fibrinogen αEC and fibrinogen γ’ splice variation on clot structure and function and also discuss the additional role of fibrinogen γ’ as thrombomodulin II. Furthermore, the effects of cross-linking on clot function will be described. Splice variation and cross-linking are major determinants of the structure and function of fibrin and may therefore impact on diseases affecting bleeding, thrombosis and tissue repair.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 Elsevier B.V. This is an author produced version of a paper published in Matrix Biology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Fibrinogen; Splice-variant; Cross-linking; Fibrin clot |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Genetics, Health and Therapeutics (LIGHT) > Academic Unit of Cardiovascular Medicine (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 27 Oct 2016 15:34 |
Last Modified: | 02 Oct 2017 12:19 |
Published Version: | https://doi.org/10.1016/j.matbio.2016.09.010 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.matbio.2016.09.010 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:106660 |