Bishop, N. orcid.org/0000-0001-7263-8546 (2016) Bone Material Properties in Osteogenesis Imperfecta. Journal of Bone and Mineral Research, 31 (4). pp. 699-708. ISSN 0884-0431
Abstract
Osteogenesis imperfecta entrains changes at every level in bone tissue, from the disorganisation of the collagen molecules and mineral platelets within and between collagen fibrils, to the macro-architecture of the whole skeleton. Investigations using an array of sophisticated instruments at multiple scale levels have now determined many aspects of the effect of the disease on the material properties of bone tissue. The brittle nature of bone in osteogenesis imperfecta reflects both increased bone mineralisation density – the quantity of mineral in relation to the quantity of matrix within a specific bone volume – and altered matrix-matrix and matrix mineral interactions. Contributions to fracture resistance at multiple scale lengths are discussed, comparing normal and brittle bone. Integrating the available information provides both a better understanding of the effect of current approaches to treatment – largely improved architecture and possibly some macro-scale toughening - and indicates potential opportunities for alternative strategies that can influence fracture resistance at longer length scales.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This is the peer reviewed version of the following article: Bishop, Nick. "Bone Material Properties in Osteogenesis Imperfecta." Journal of Bone and Mineral Research 31.4 (2016): 699-708., which has been published in final form at http://dx.doi.org/10.1002/jbmr.2835. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 24 Aug 2016 09:33 |
Last Modified: | 30 Oct 2016 19:30 |
Published Version: | http://dx.doi.org/10.1002/jbmr.2835 |
Status: | Published |
Publisher: | American Society for Bone and Mineral Research (ASBMR) |
Refereed: | Yes |
Identification Number: | 10.1002/jbmr.2835 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:104010 |