Iman, A, Fairley, L orcid.org/0000-0002-4280-6323, Parslow, RC orcid.org/0000-0002-3945-5294 et al. (1 more author) (2016) Population mixing and incidence of cancers in adolescents and young adults between 1990 and 2013 in Yorkshire, UK. Cancer Causes and Control, 27 (10). pp. 1287-1292. ISSN 0957-5243
Abstract
Purpose: Epidemiological evidence suggests a role for an infectious etiology for cancers in teenagers and young adults (TYAs). We investigated this by describing associations between infection transmission using the population mixing (PM) proxy and incidence of cancers in TYAs in Yorkshire, UK. Methods: We extracted cancer cases from the Yorkshire Specialist Register of Cancer in Children and Young People from 1990 to 2013 (n = 1929). Using multivariable Poisson regression models (adjusting for effects of deprivation and population density), we investigated whether PM was associated with cancer incidence. We included population mixing–population density interaction terms to examine for differences in effects of PM in urban and rural populations. Results: Nonsignificant IRRs were observed for leukemias (IRR 1.20, 95% CI 0.91–1.59), lymphomas (IRR 1.09, 95% CI 0.90–1.32), central nervous system tumors (IRR 1.06, 95% CI 0.80–1.40) and germ cell tumors (IRR 1.14, 95% CI 0.92–1.41). The association between PM and cancer incidence did not vary in urban and rural areas. Conclusions: Study results suggest PM is not associated with incidence of cancers among TYAs. This effect does not differ between rural and urban settings.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author(s) 2016. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
Keywords: | Cancer; Teenagers and young adults; Population Mixing |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Genetics, Health and Therapeutics (LIGHT) > Division of Epidemiology & Biostatistics (Leeds) |
Funding Information: | Funder Grant number Candlelighters No Ext Ref Given |
Depositing User: | Symplectic Publications |
Date Deposited: | 11 Aug 2016 11:10 |
Last Modified: | 05 Oct 2017 16:25 |
Published Version: | http://dx.doi.org/10.1007/s10552-016-0797-3 |
Status: | Published |
Publisher: | Springer Verlag |
Identification Number: | 10.1007/s10552-016-0797-3 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:103549 |