Jiang, LH orcid.org/0000-0001-6398-0411, Hao, Y, Mousawi, F orcid.org/0000-0003-2267-2652 et al. (2 more authors) (2017) Expression of P2 Purinergic Receptors in Mesenchymal Stem Cells and their Roles in Extracellular Nucleotide Regulation of Cell Functions. Journal of Cellular Physiology, 232. 2. pp. 287-297. ISSN 0021-9541
Abstract
Extracellular ATP and other nucleotides induce autocrine and/or paracrine purinergic signalling via activation of the P2 receptors on the cell surface, which represents one of the most common signalling mechanisms. Mesenchymal stem cells (MSC) are a type of multipotent adult stem cells that have many promising applications in regenerative medicine. There is increasing evidence to show that extracellular nucleotides regulate MSC functions and P2 receptor-mediated purinergic signalling plays an important role in such functional regulation. P2 receptors comprise ligand-gated ion channel P2X receptors and G-protein-coupled P2Y receptors. In this review, we provide an overview of the current understanding with respect to expression of the P2X and P2Y receptors in MSC and their roles in mediating extracellular nucleotide regulation of MSC proliferation, migration and differentiation.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2016, Wiley. This is the peer reviewed version of the following article: "Jiang, L.-H., Hao, Y., Mousawi, F., Peng, H. and Yang, X. (2016), Expression of P2 Purinergic Receptors in Mesenchymal Stem Cells and Their Roles in Extracellular Nucleotide Regulation of Cell Functions. J. Cell. Physiol." which has been published in final form at http://dx.doi.org/10.1002/jcp.25484. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > Oral Biology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 04 Aug 2016 11:21 |
Last Modified: | 18 Jul 2017 05:48 |
Published Version: | http://dx.doi.org/10.1002/jcp.25484 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/jcp.25484 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:103327 |