Di Martino, E, Tomlinson, DC orcid.org/0000-0003-4134-7484, Williams, SV et al. (1 more author) (2016) A place for precision medicine in bladder cancer: targeting the FGFRs. Future Oncology, 12 (19). pp. 2243-2263. ISSN 1479-6694
Abstract
Bladder tumors show diverse molecular features and clinical outcome. Muscle-invasive bladder cancer has poor prognosis and novel approaches to systemic therapy are urgently required. Non-muscle-invasive bladder cancer has good prognosis, but high recurrence rate and the requirement for life-long disease monitoring places a major burden on patients and healthcare providers. Studies of tumor tissues from both disease groups have identified frequent alterations of FGFRs, including mutations of FGFR3 and dysregulated expression of FGFR1 and FGFR3 that suggest that these may be valid therapeutic targets. We summarize current understanding of the molecular alterations affecting these receptors in bladder tumors, preclinical studies validating them as therapeutic targets, available FGFR-targeted agents and results from early clinical trials in bladder cancer patients.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 Future Medicine Ltd. This is an author produced version of a paper published in Future Oncology. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Experimental Oncology (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cancer and Pathology (LICAP) > Section of Experimental Oncology (Leeds) |
Funding Information: | Funder Grant number Yorkshire Cancer Research L372 Cancer Research UK C6228/A5569 Cancer Research UK C6228/A5433 Cancer Research UK C6228/A5433 Yorkshire Cancer Research L346 Cancer Research UK C6228/A12512 Yorkshire Cancer Research L367 Yorkshire Cancer Research LPP034 Yorkshire Cancer Research Not Known Yorkshire Cancer Research L376PA |
Depositing User: | Symplectic Publications |
Date Deposited: | 12 Jul 2016 15:46 |
Last Modified: | 04 Nov 2017 16:30 |
Published Version: | http://dx.doi.org/10.2217/fon-2016-0042 |
Status: | Published |
Publisher: | Future Medicine |
Identification Number: | 10.2217/fon-2016-0042 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:102184 |