Castro-Osma, José A. orcid.org/0000-0002-5029-0507, Earlam, Amy, Lara-Sánchez, Agustín et al. (2 more authors) (2016) Synthesis of Oxazolidinones from Epoxides and Isocyanates Catalysed by Aluminium Heteroscorpionate Complexes. ChemCatChem. 2100–2108. ISSN 1867-3899
Abstract
The combination of an aluminium(heteroscorpionate) complex and tetrabutylammonium bromide acts as a highly efficient catalyst system for the synthesis of oxazolidinones from epoxides and isocyanates. Twenty two complexes were tested derived from a range of bispyrazole ligands and containing 1-3 aluminium atoms per complex. The optimal catalyst was found to be a bimetallic complex of a thioacetamidate ligand. Under the optimal reaction conditions (80°C in toluene for 24h using 5mol% of both aluminium catalyst and tetrabutylammonium bromide co-catalyst), six epoxides were reacted with six aromatic isocyanates, giving 25 oxazolidinones in moderate to excellent yields showing broad substrate scope. The regiochemistry of the reaction (to produce 3,4- or 3,5-oxazolidinones) is controlled by the substrate with epoxide ring opening occurring preferentially at the less hindered end of the epoxide unless a substituent on the epoxide can stabilise a positive charge.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © Wiley 2016. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details |
Keywords: | Aluminium,Heterocycles,Homogeneous catalysis,Ligand effects,Regioselectivity |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 29 Jun 2016 12:31 |
Last Modified: | 16 Oct 2024 13:06 |
Published Version: | https://doi.org/10.1002/cctc.201600407 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1002/cctc.201600407 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:101615 |