Stratton-Powell, AA and Tipper, JL orcid.org/0000-0002-8719-0323 (2016) Characterization of UHMWPE Wear Particles. In: Kurtz, SM, (ed.) UHMWPE Biomaterials Handbook: Ultra High Molecular Weight Polyethylene in Total Joint Replacement and Medical Devices. Elsevier , pp. 635-653. ISBN 9780323354011
Abstract
Although most total joint prostheses remain stable for many years, a significant proportion experience loosening, with about 10% requiring revision 10 years after primary arthroplasty. It is generally accepted that osteolysis, among other causes, is initiated by the biological response to wear particles, which are released from ultra high molecular weight polyethylene acetabular liners and tibial trays. Wear particles up to 10 μm in size are predicted to be phagocytosed by resident macrophages and cause the release of inflammatory cytokines and chemokines, including tumor necrosis factor alpha (TNF-α), interleukin-1beta (IL-1β, IL-6, and IL-8. These cytokines stimulate the release of other mediators and the ensuing inflammatory cascade results in the formation of a periprosthetic granulomatous tissue reaction. Histopathological studies have revealed that these inflammatory cytokines facilitate osteoclastagenesis, which results in resorption of bone and a painfully loose implant. Revision surgery is currently the only option for the patient and surgeon.
Metadata
Item Type: | Book Section |
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Authors/Creators: |
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Editors: |
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Keywords: | UHMWPE; total joint prostheses; wear particles; histopathology; arthroplasty; osteolysis |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Mechanical Engineering (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 09 Mar 2017 15:41 |
Last Modified: | 09 Mar 2017 15:41 |
Published Version: | http://www.sciencedirect.com/science/article/pii/B... |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/B978-0-323-35401-1.00033-8 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:100837 |